Elastase-coupled beads resulted in a quantifiable loss of alveolar tissue immediately surrounding the beads, an effect that was not observed with beads that lacked protein altogether or with beads containing elastase inactivated by an irreversible inhibitor.

C57BL/6 mice were given a single dose of 40,000 beads, which became distributed throughout the small airways and parenchyma of the lung. Elastase was coupled to bisacrylamide beads, which were shown to retain enzymatic activity prior to intratracheal administration in mice. Here we establish a bead-based elastase delivery system that induces localized tissue destruction, a key event in the initiation of emphysema. However, instillation of elastase suspended in buffer results in widespread inflammation and variable emphysematous lesions, which has made the identification of specific cellular and molecular events associated with the onset of emphysema difficult to define. Ride more and shop our online store for Bead Breakers, tire irons, tire changing hand tool, accessories, and full-line of spare parts.Intratracheal elastase challenge of laboratory animals has long been established as a model for observing the physiological and morphological changes that result from alveolar destruction, the hallmark of emphysema. We stand behind the quality of our products and provide rock-solid warranties no matter what type of abuse you throw at them. Our Bead Breakers work with any size wheel and rim including ATV’s, adventure bikes, track cars, off-road trucks, farm tractors, and trailers. Our high-quality, Made-in-USA XB-45x BeadBuster series are easy to use and come in four different model specs to support the casual weekend trail rider, all the way up to professional race teams. BeadBuster’s goal is designing the best possible portable bead breaking tools to easily change your tires at home or on the trail, that do the job properly and efficiently, every time.

Knowing we could do it better, we designed the most affordable and effective bead breaker to date, the BeadBuster Bead Breaker. BeadBuster was founded by a pair of avid Powersports enthusiasts and DIY mechanics who were frustrated with the current selection of manual tire changing hand tools/expensive dealership service charges for swapping tires on their ATV’s and adventure bikes.

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